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A
nanoscale computer—programmed to find cancer
cells and release DNA molecules to eradicate them—has
been shown to work in test tubes. Researchers at the
Weizmann Institute in Israel hope they will eventually
get these miniscule computers to work in the human
body.
The researchers used the simple molecular
computer which they developed three years ago by adding “input” and “output” modules
composed of DNA. The computer is then programmed with
medical knowledge to determine whether the signal it
was sensing indicates disease output modules. If cancer
is diagnosed, the output unit of the computer will activate
a controlled release of a single-stranded DNA molecule
which will cause the cancer cell’s activities to
self-destruct.
In one series of test-tube experiments,
the computer successfully identified RNA molecules indicating
the presence of prostate cancer and at another time the
signs of one form of lung cancer.
Their research gives hope to future development
of a ‘smart’ drug molecule which holds the
drug in an inactive state and is encoded for release
only when the disease exists in the human body. (Source:
NanoBiotech News, May 12, 2004)
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